With millions of people preparing to travel for the Thanksgiving holiday, two strong storm systems are forecast to bring snow, wind and rain across a large swath of the United States this week.

But starting this week, Mother Nature is throwing another wrench into everyone’s travel plans: A widespread winter storm is expected to bring freezing temperatures, harsh winds, lots of rain, and snow.

A powerful winter storm is set to blast portions of the U.S. with accumulating snow, cold temperatures, strong winds and rain just as millions of people across the country prepare to travel early for Thanksgiving.