DeSantis and opponents to Amendment 4 argued the ballot measure's authors are "lying" to Floridians, and words used, like "health care provider" and "viability" leave too much room for "outsiders" and unqualified practitioners to come to Florida and perform unsafe procedures.

DeSantis led an aggressive, months-long campaign against Amendment 3, which sought to legalize recreational marijuana, and Amendment 4, which would have broadened abortion access in the state — frequently leveraging the power of state government and using taxpayer dollars to defeat the measures.