The losses are the first on statewide reproductive rights ballot measures anywhere in the U.S. since the Supreme Court overturned Roe v. Wade in 2022, a ruling that struck down the nearly 50-year nationwide right to abortion, proving that abortion opponents can win on ballot measures.

The Associated Press projected passage of Amendment 3, an amendment that will enshrine abortion-rights protections in Missouri's constitution.

Voters narrowly approved Amendment 3 on Nov. 5, which adds a “fundamental right to reproductive freedom” to the state constitution, threatening to undo decades of pro-life gains.